The anthelmentic effects of Fuadin (sodium antimony-lll-bis-pyrocatechin-disulphonate), Bithionol 2-2-thiobis 4,6-dichlorophenol)), hexachlorethane and carbon tetrachloride were studied on Eurytrema pancreaticum infected in sheep and goats. The evaluation on the effects was based upon the egg reduction in the feces of the experimental animals administered the drugs.
The number of eggs per 5gm. of the feces was respectively calculated before the treatments, and the follow-up for the egg reductions was carried out over a period of three or four weeks(calculated twice a week).
Oral administration of Bithionol (once a day for 2 succeed days, at the rate of 75 ㎎ per ㎏ of bady weight) and of hexachlorethane (once a day, at the rate of 300㎖ per ㎏ of body weight; did not reveal any egg reduction in sheep host.
lntramuscular injection of carbon tetrachloride with olive oil (once a day, at the rate of 0.05㎖ per ㎏ of body weight) did not show the egg reduction in goats.
Intramuscular injectjons of Fuadin for 5 days (the dosage schedule was 0.5㎖ at 1st day, 1.0㎖ at 2nd and 3rd day, 1.5㎖ at 4th and 5th day, to amount of 5.5㎖) were completely devoid the fluke eggs in the feces of goats on 4 weeks after each treatment.
Throughout the studies, Fuadin was only proved its anthelmintic effect to the goats infected with E. pancreaticum. On the other hand, Bithional, hexachlorethane and carbon tetrachloride did not reveal any effect as Fuadin showed.
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